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Preheat the oven to 400°F.
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Wrap the potatoes in foil and bake for about 60 minutes, or until tender.
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Brown the ground bison in a skillet over medium-high heat, breaking it apart as it cooks. Season with salt and pepper.
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Slice the baked potatoes in half lengthwise. Scoop out the centers, leaving enough potato around the edges to support the skins.
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Combine the browned ground bison with the potato filling.
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Add the sautéed onions, green onions, ketchup, mustard, sweet pickle relish and milk.
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Mix until combined, keeping the filling thick and chunky.
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Spoon the filling into the potato skins and place them on a baking sheet.
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Bake for another 20 minutes.
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Top with cheese, pickles, ketchup, mustard, sour cream or your favorite burger toppings.